Can Osteogenesis Imperfecta Be Inherited?

What organs are affected by osteogenesis imperfecta?

In more severe forms of osteogenesis imperfecta, there may be bone deformities, poor lung development and lung problems, a barrel-shaped chest, poor muscle development in the arms and legs.

Osteogenesis imperfecta is caused by a faulty gene that affects the body’s ability to produce collagen..

What disease does Byron Baxter have?

That’s because Byron is living with a brittle bone disease, a rare genetic condition with no cure. Doctors call it osteogenesis imperfecta, which means “imperfectly formed bone.”

What is an OI baby?

Your child has been diagnosed with osteogenesis imperfecta (OI). This is a rare condition that causes bones to be very thin and delicate so they break (fracture) easily. OI is sometimes called brittle bone disease. There are four types of OI that range from mild to severe.

Is Osteogenesis Imperfecta hereditary?

When caused by mutations in the COL1A1 or COL1A2 gene, osteogenesis imperfecta has an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to cause the condition.

How is brittle bone disease inherited?

Brittle bone disease is passed down through families, or inherited. It’s caused by a defect in a gene that is supposed to make a substance called collagen. Collagen is a protein in your body that forms and strengthens bones. If you don’t have enough of it, your bones become very weak and will break easily.

How long can you live with brittle bone disease?

It is estimated that approximately 25,000 to 50,000 people in the U.S. have OI. With good medical management and supportive care, the majority of people who have OI will lead healthy, productive lives and can expect an average lifespan. People with OI experience frequent broken bones from infancy through puberty.

Who is at risk for osteogenesis imperfecta?

An estimated 20,000 to 50,000 people in the U.S. have the condition. The estimated number varies greatly because milder forms of osteogenesis imperfecta can go undiagnosed. The greatest risk factor is heredity. If one parent has osteogenesis imperfecta, a child has a 50 percent chance of having the condition.

What is wrong with Byron the Baxter boy?

When you listen to 3-year-old Byron Baxter laugh and talk, you’d never know anything was wrong with him. But he was born with a rare condition called osteogenesis imperfecta, or brittle bone disease.

Does brittle bone disease affect teeth?

It is also known as brittle bone disease where bones sometimes break for no known reason. OI can also cause many other problems, such as weak muscles, brittle teeth, and hearing loss.

What is the life expectancy of someone with osteogenesis imperfecta?

Outlook / Prognosis Most children born with type I OI live normal, healthy lives into adulthood. Less severe symptoms do not affect life expectancy. Most OI-related deaths result from respiratory failure due to weak lungs. The most severe types will result in death at birth or soon after.

Does osteogenesis imperfecta get worse with age?

It causes bones to break easily. In type 3 OI, your child’s body produces enough collagen but it’s poor quality. Your child’s bones can even begin to break before birth. Bone deformities are common and may get worse as your child gets older.

Is Osteogenesis Imperfecta painful?

Background: Pain is a common symptom of osteogenesis imperfecta (OI) among children and adolescents.

Where is osteogenesis imperfecta most common?

OI type II is estimated to occur in one in 60,000 live births. The overall prevalence of all types of OI is estimated at . 5 per 10,000 individuals in the United States. Approximately 20,000 to 50,000 individuals in the United States have OI.

Is Osteogenesis Imperfecta a disability?

Although Type II Osteogenesis Imperfecta is one of the 88 conditions that qualifies a disability claim for processing under the Compassionate Allowances guidelines, that does not mean that your child’s claim will be automatically approved by the Social Security Administration.

Is Osteogenesis Imperfecta a type of dwarfism?

Osteogenesis imperfecta (OI) Type III is a dwarfism condition, with adults generally reaching a height of three feet, although profound short stature is often associated with the other three types as well.

How can osteogenesis imperfecta be prevented?

Light exercise and low impact physical activity like swimming and walking are suggested to keep the muscles strong and agile, and strengthen the bones. In severe OI cases, inserting a metal rod through surgery or bracing is suggested to strengthen the bone and reduce the risk of fractures.